Copyright @ 2018 Actorius Innovation and Research Pvt Ltd

Novel Drug Delivery Systems (NDDS)

We have designed a novel gastro-retentive-pulsatile release system. The significance of this platform is in achieving the drug delivery as a chrono-therapeutic release (with varying lag period). 

 

Conventional controlled releasing drug delivery systems have limited clinical utility for those drugs having narrow absorption window in the gastrointestinal tract (GIT) due to its absorption primarily in duodenum and/or jejunum. On the other hand, pharmaceutical dosage forms which are retained in the stomach for a prolonged period of time after oral administration and release the active ingredient in a controlled manner are critical for delivery of a wide variety of drugs.

 

The superhydrodynamic trait of the dosage form allows it to float in stomach for a longer time. The drug is incorporated in the matrix of this polymer. In addition the release of the drug is controlled as a lag from 0-5 hours using a combination of polymer protection. Thereafter the drug starts releasing in a controlled release profile.

 

The prudent clinical objective of the proposed platform technology is to achieve the local therapeutic absorption in the upper part of the small intestine. The technology is currently undergoing clinical testing and validation.